iPSC-derived neuronal models PostDoc positions and fellowships

This postdoctoral fellowship focuses on deciphering the neurotoxic mechanisms of chitinase 3-like 1 (CHI3L1) in progressive multiple sclerosis and identifying therapeutic compounds that block its pathogenic effects. The successful candidate will work within the Clinical Neuroimmunology Group at VHIR, utilizing human iPSC-derived neuronal models, molecular and cellular biology, advanced imaging, transcriptomic and proteomic approaches, and drug screening strategies to uncover intracellular mediators, neuronal receptors, and potential drug candidates for progressive MS therapy.

This postdoctoral associate position in the Department of Neurosurgery at Rutgers Biomedical and Health Sciences focuses on investigating disease mechanisms of various brain disorders using murine models and iPSC-derived human neurons. The role involves performing small animal surgeries, molecular, cellular, and electrophysiological experiments, analyzing intracranial EEG data, developing computational pipelines in MATLAB and Python, and contributing to grant writing and manuscript preparation for peer-reviewed journals.

This postdoctoral position in the Department of Genetics at Washington University in St. Louis focuses on Personalized Medicine research investigating disease-associated genetic variants using iPSC-derived neurons and glia models. The research explores neurodevelopmental, neuropsychiatric, and neurodegenerative disorders with emphasis on mitochondrial dysfunction and metabolic deficits.

A postdoctoral position at the University of Luxembourg's LCSB focuses on neurodegenerative disease research using iPSC models, metabolism assays, and computational modeling. The role involves interdisciplinary collaboration, data analysis, manuscript writing, and teaching support.

This fully funded PhD studentship at the University of Surrey investigates the role of extracellular vesicles in hypertrophic cardiomyopathy, using human iPSC-derived cardiomyocytes to study cell‑cell signalling, structural and functional changes, and molecular pathways that drive disease progression. The project offers training in cell culture, vesicle isolation, advanced microscopy, cardiac functional assays and proteomics, preparing candidates for careers in cardiovascular research, stem cell biology or translational medicine.

The University of Miami seeks a Post Doctoral Associate to conduct research in cardiovascular biology, heart failure, and regenerative medicine at their Interdisciplinary Stem Cell Institute. The role involves independent research, molecular assays, data analysis, manuscript preparation, and mentoring under supervision.

This post-doctoral fellowship focuses on establishing and optimizing protocols for differentiating motor neurons from patient‑derived induced pluripotent stem cells (iPSCs) and applying cutting‑edge single‑cell proteomics to uncover disease‑relevant protein signatures in neuronal development. The researcher will integrate proteomic data with transcriptomics and imaging, collaborate with clinical partners on Parkinson’s and Alzheimer’s disease, and gain hands‑on experience with state‑of‑the‑art mass spectrometry instrumentation and computational analysis within an international, collaborative research environment at the Luxembourg Institute of Health.

This postdoctoral fellowship at the Luxembourg Institute of Health focuses on applying single-cell proteomics to study neuronal development using patient-derived induced pluripotent stem cells (iPSCs). The successful candidate will differentiate iPSCs into motor neurons, establish and optimize single-cell proteomics workflows, and integrate proteomic data with transcriptomics and imaging to uncover disease-relevant molecular signatures in Parkinson’s and Alzheimer’s disease. The position offers training in cutting-edge mass spectrometry, bioinformatics, and interdisciplinary collaboration within an international team.

The successful candidate will join the Wellcome-funded project on context-dependent RNA regulation and auto-gating therapeutics for brain disorders, based at the Francis Crick Institute within the joint Blencowe/Ule satellite lab. The role involves designing and testing auto-gating therapeutics in iNeuron models of neurological diseases, generating and culturing induced pluripotent stem cell (iPSC) lines, differentiating them into neurons, and performing transcriptomic and imaging analyses. Collaboration with team members, supervision of visiting students, and contribution to publications and conference presentations are expected.

This PhD position focuses on understanding the mechanisms of juvenile dermatomyositis (JDM), an autoimmune disease in children characterized by skin and muscle inflammation, vasculopathy, and interferon‑I (IFN‑I) dysregulation. The project investigates how RNA viral infection triggers uncontrolled IFN‑I production in predisposed children, leading to muscle ischemia, capillary loss, and myofibre atrophy. Using patient‑derived induced pluripotent stem cells (iPSCs), the candidate will generate endothelial and muscle cells to study vasculopathy and IFN‑I‑induced stress in co‑culture experiments. The work integrates chemical synthesis, protein chemistry, redox biology, molecular modelling, and immunological assays to clarify RNA sensor signalling pathways and identify novel therapeutic targets.