drug screening PostDoc positions and fellowships

This postdoctoral fellowship focuses on deciphering the neurotoxic mechanisms of chitinase 3-like 1 (CHI3L1) in progressive multiple sclerosis and identifying therapeutic compounds that block its pathogenic effects. The successful candidate will work within the Clinical Neuroimmunology Group at VHIR, utilizing human iPSC-derived neuronal models, molecular and cellular biology, advanced imaging, transcriptomic and proteomic approaches, and drug screening strategies to uncover intracellular mediators, neuronal receptors, and potential drug candidates for progressive MS therapy.

A postdoctoral research associate position is available at the University of Nebraska Medical Center’s Department of Biochemistry and Molecular Biology. The project focuses on developing and testing novel combination drug therapies for glioblastoma using advanced cell culture, 3D models, drug screening, fluorescence microscopy, and in vivo preclinical studies. The successful candidate will conduct animal genotyping, drug treatment, and breeding experiments, and is expected to have a PhD in Biochemistry, Biomedical Sciences, or Life Sciences, strong cancer biology expertise, and a track record of first‑author publications.

This PhD project develops integrative in silico and ex vivo approaches to identify personalized therapeutic strategies for KRAS-mutated lung adenocarcinomas using AI models and patient-derived tumor organoids.

This postdoctoral position at ETH Zürich’s Singapore-ETH Centre focuses on developing patient‑derived 3D bone organoid models for personalized osteoporosis drug screening. The researcher will optimize workflows to 3D‑print mesenchymal stromal cells, guide osteogenic differentiation under dynamic mechanical stimulation, co‑culture with peripheral blood mononuclear cells, and assess donor‑specific responses to pharmacological interventions. The project integrates molecular, biochemical, histological, imaging and microscopy techniques to study osteoporosis‑related remodelling, immune‑bone interactions, age‑related comorbidity effects and fracture risk, contributing to predictive modelling frameworks for precision musculoskeletal care.

This PhD position at the St. Anna Children's Cancer Research Institute in Vienna focuses on computational cancer research, integrating large-scale multi-omics data such as whole genome sequencing, targeted sequencing, and high-throughput drug sensitivity screens to develop predictive models for relapse risk. The candidate will design independent projects, apply machine learning and statistical methods, collaborate with biologists and clinicians, and disseminate findings through publications and conferences.

The Ohio State University seeks a highly motivated Postdoctoral Scholar to join the Thege Laboratory in the Division of Surgical Oncology. The position focuses on developing rational drug combinations for KRAS‑mutant pancreatic and lung cancers, using patient‑derived organoids, genetically engineered mouse models, CRISPR activation screens, and multi‑omic profiling (scRNA‑seq, spatial transcriptomics, bulk RNA‑seq) to uncover therapeutic vulnerabilities and resistance mechanisms.

This postdoctoral position at the Institute of Bioorganic Chemistry, Polish Academy of Sciences focuses on drug design and high-throughput screening to identify enzyme inhibitors targeting macromolecular structures. The successful candidate will join a multidisciplinary team led by Prof. Magdalena Łuczak and Prof. Miłosz Ruszkowski, employing biophysical, computational, and cellular approaches to optimize compounds with therapeutic potential. The role involves in vitro, cellulo, and in silico studies, contributing to the POL-OPENSCREEN infrastructure project for chemical biology screening in Poland.

The Myers Lab at Harvard University seeks a Post‑Doctoral Fellow to work on antibiotic drug discovery through state‑of‑the‑art organic synthesis. The role involves designing and synthesizing antibiotic compounds from milligram to multi‑gram scale, evaluating biological activity, publishing results, collaborating on interdisciplinary projects, and contributing to teaching and mentoring. A Ph.D. in organic chemistry and strong laboratory expertise are required.

A fully funded 4-year PhD studentship at Newcastle University focused on designing and synthesising novel hydrophobic warheads for targeted covalent inhibitors, using Fraglite design, fragment screening by NMR/X-ray, and iterative design-make-test cycles against high-value cancer targets.

The Liau Lab at Harvard University seeks a Post-Doctoral Fellow to investigate the molecular mechanisms underlying biological processes, cancer mutations, and drug action using chemical biology and genomics. The role requires a Ph.D., strong research record, excellent communication skills, and the ability to work independently in a multidisciplinary environment.

Postdoctoral Fellow position in the Liau Lab at Harvard University studying molecular mechanisms of biological processes, cancer mutations, and drug mechanisms using chemical biology and genomics approaches.

The Miao Lab at UNC-Chapel Hill seeks a Postdoctoral Research Associate to develop AI-driven computational methods for drug discovery and biomolecular simulations. The role focuses on accelerating molecular recognition and cellular signaling studies, with collaboration opportunities on therapeutically important targets like GPCRs and RNA.